Tetsuya Yamada, associate professor at Tohoku University, and his research team, have discovered new information regarding a bodily mechanism that causes obesity in experimented mice. In an article in the U.S. journal Cell Metabolism published recently, Yamada said that animals “may have a system to store excess calories they have ingested, in order to prepare for starvation.” Based on their experiment, when the mice ingested high-calorie food, their brains curbed the activity of energy-consuming brown fat cells, resulting to an easier storage of nutrients in their bodies.
The focus of the experiment was glucokinase, an enzyme in the liver, pancreas, gut, and brain that enhances sugar metabolism. It was found that in mice that were fed with high-caloric food, their glucokinase rose. The response of the brain was to curb a sympathetic nerve and reduce energy consumption by the brown fat cells. On the other hand, there were no changes in the brown fat cell activity in mice whose nerves between the brain and liver had been cute.
In the same article, it was said that the team likewise compared mice that are inclined to become fat from those that are not. Essentially, in the obesity risk group, mice used more energy when an increase in their glucokinase was curbed.
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